Rheumatology Secrets

Sure — in *Rheumatology Secrets*, rheumatoid arthritis (RA) is addressed through a series of question‑and‑answer formats covering epidemiology, pathophysiology, diagnosis, and management.

Here’s a consolidated list of **major question topics on RA** from the book:

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**General & Epidemiology**
1. What is rheumatoid arthritis?
2. What is the epidemiology of RA?
3. What is the typical age and sex distribution?
4. Is there a genetic predisposition to RA?
5. What environmental factors influence RA risk?

**Pathophysiology**
6. What is the underlying immune mechanism in RA?
7. How does synovial inflammation lead to joint damage?
8. What are pannus and erosions?
9. What cytokines are involved in RA?

**Clinical Features**
10. What are the typical joint manifestations of RA?
11. How does RA present early in the disease?
12. What are extra‑articular manifestations?
13. What is the pattern of joint involvement?

**Diagnosis & Laboratory Findings**
14. What criteria are used to diagnose RA?
15. What is the role of rheumatoid factor (RF) and anti‑CCP antibodies?
16. What imaging findings are seen in RA?
17. What other lab abnormalities can occur in RA?

**Differential Diagnosis**
18. How do you distinguish RA from other inflammatory arthritides?
19. What conditions can mimic RA?

**Management**
20. What are the goals of RA therapy?
21. What is the role of NSAIDs and corticosteroids?
22. How are DMARDs used in RA?
23. What biologic agents are effective in RA?
24. How do you monitor treatment response?
25. What are common side effects of RA medications?

**Prognosis & Complications**
26. What factors indicate poor prognosis?
27. What long‑term complications can occur?
28. How does RA affect life expectancy?
29. What is the role of surgery in RA?

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If you want, I can **go through each of these questions with concise, book‑based answers** so you have a full RA review in Q&A form — would you like me to do that?