Molecular Pharmacology: From DNA to Drug Discovery

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecularContent: Chapter 1 Introduction to Drug Targets and Molecular Pharmacology (pages 1–12): Chapter 2 Molecular Cloning of Drug Targets (pages 13–29): Chapter 3 G Protein?Coupled Receptors (pages 31–70): Chapter 4 Ion Channels (pages 71–128): Chapter 5 Transporter Proteins (pages 129–174): Chapter 6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease (pages 175–199): Chapter 7 Pharmacogenomics (pages 201–226): Chapter 8 Transcription Factors and Gene Expression (pages 227–276): Chapter 9 Cellular Calcium (pages 277–313): Chapter 10 Genetic Engineering of Mice (pages 315–337): Chapter 11 Signalling Complexes: Protein?Protein Interactions and Lipid Rafts (pages 339–365): Chapter 12 Recombinant Proteins and Immunotherapeutics (pages 367–380):